UVB irradiation leads to increased apoptosis in NRP1-deficient epidermis in vivo.

Abstract

<p>To investigate UVB-induced apoptosis in vivo epidermis-specific NRP1 knock out mice and control animals were irradiated with 1 J/cm². 24 hours later skin biopsies were stained for active caspase 3 in control (A) or knock out (B) animals. Apoptotic cells were counted and analyzed for statistically significant differences (C). Additionally, apoptotic cells were stained by TUNEL assays (D, E) and cells were quantified (F). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050944#pone-0050944-g004" target="_blank">Figure 4</a> (A to F) shows one representative example out of three independent experiments.</p