Insulin, glucagon and type 2 diabetes susceptibility gene expression in diabetic sorted islet cells.

Abstract

<p>A: Differential expression of beta cell insulin and alpha cell glucagon in non-diabetic (white bars) compared to diabetic (black bars) islet cells. B: Expression levels of type 2 diabetes susceptibility gene in diabetic alpha cells (white bars) and beta cells (black bars). C: Differential expression of <i>FTO</i> in both cell fractions from non-diabetic (white bars) compared to diabetic (black bars) islet cells. Statistical comparison of diabetic to non-diabetic samples was by unpaired T test assuming unequal variance. n = 16 non-diabetic and 3 diabetic samples.</p