The IFN-β response in mDC is IRF-1, IRF-8, IFN-α/β-independent but partially IRF-5-dependent.

Abstract

<p>mDC generated from wild type, (A and B) IRF-1^−/−, IRF-8^−/−, (C and D) IFN-α/βR^−/−, or (E and F) IRF-5^−/− mice were infected at an MOI of 0.1 and levels of IFN-α (A, C, and E) and IFN-β (B, D, and F) mRNA were measured by qRT-PCR. Values are an average of triplicate samples generated from three independent experiments. Asterisks indicate values that are statistically significant (***, P<0.0001, **, P<0.005, *, P<0.05) compared to wild type.</p