Co-aggregation of α-synuclein with DOPC:DOPS 7∶3 (a, c) and DOPC (d, f) at L/P = 18 (molar ratio).

Abstract

<p>Left: Lipid concentration derived from quantitative phosphorous analysis of aggregated and non-aggregated lipids after co-aggregation with 34 µM α-synuclein (a, d). Right: Polarization transfer solid state NMR on lamellar phase lipids (b, e) and lipids co-aggregated with α-synuclein (c, f). Stars indicate peaks originating from buffer molecules. Spectra are normalized to equal intensity for DP of C₁₈.</p