PXD101 induces apoptosis in BHP7-13, WRO82-1 and 8505C.

Abstract

<p>A, apoptosis was analyzed by measurements of DNA content using flow cytometry at 48 and 72 hours. Increasing doses of PXD101 induced higher proportion of sub-G1 cells in all cell lines. B, immunoblot showed PXD101 degraded executioner caspase-3 in three cell lines.</p