Granzyme B and perforin contribute to plaque development in the descending aorta of apolipoprotein Eknockout mice.

Abstract

<p>(A) Representative images on the descending aorta from high fat diet-fed apolipoprotein E knockout (ApoE KO), granzyme B (GzmB)/ApoE double knockout (DKO) and perforin (Prf1)/ApoE DKO mice stained en face with sudan IV. (B) When plaque area was quantified, GzmB/ApoE DKO mice (n = 22) had significantly reduced plaque area compared to ApoE KO mice (n = 16). Prf1/ApoE DKO mice (n = 14) had significantly less plaque than both the ApoE KO mice and the GzmB/ApoE DKO mice. *<i>P</i><0.05, ***<i>P</i><0.005 (One-way ANOVA with bonferonnipost test). Error bars represent SEM.</p