Granzyme B and perforin are present in atherosclerotic plaques from apolipoprotein E knockout mice.

Abstract

<p>(A)Representative images of aorta cross sections from high fat diet-fed wild type (WT),apolipoprotein E knockout(ApoE KO), Granzyme B (GzmB)/ApoE double knockout (DKO) and perforin (Prf1)/ApoE DKOmice stained for GzmB and Prf1. Black scale bars = 400 µm, white scale bars = 100 µm.(B)Neither GzmB nor Prf1 deficiency resulted in a significant difference in circulating levels of cholesterol (n = 4) and triglycerides (n = 7) in ApoE KO mice when fed a high fat diet for 30 weeks.</p