<p>The activity of female WT (n = 15) and female IL-1R1<sup>−/−</sup> (n = 15) mice was recorded using the Phenotyper home cage over a period of three nights and two days. Data are plotted in 4 hour blocks and are expressed as mean±SEM and were analysed by two way repeated measures ANOVA with strain as between subjects factor and time as within subjects factor. There was no effect of strain but a significant time × strain interaction, which is denoted by *p<0.0003.</p