Ventricular volume and synaptic density in WT and IL-1R1^−/− mice.

Abstract

<p>(a–c) Representative images of the hippocampus and lateral ventricle of WT (a) and IL-1R1^−/− (b) brain. Ventricular volume in WT (n = 4) and IL-1R1^−/− mice (n = 6) was assessed using Image J Software (c). Areas were calculated for sections from each animal at 2.0 and 2.3 mm posterior to Bregma and summed and multiplied by the summed section thickness (2×10 µm: 0.02 mm). Data are non-parametric and have been presented as dot plots with median value denoted by the bar. (d–i) Synaptophysin labelling in the dorsal (see inset *) and more ventral hippocampus (approximately −3.0 mm from surface of brain; see inset *) of WT (d, g) and IL-1R1^−/− mice (e, h). Synaptic density analysis of the dorsal hippocampus: ratio of stratum radiatum to dentate gyrus molecular (f) and ventral hippocampus ratio of stratum radiatum to stratum lacunosum moleculare (i) for WT (n = 4) and IL-1R1^−/− (n = 5).</p