Meloxicam inhibits phosphorylation of AKT in a COX-2-depdendent way.

Abstract

<p>(A) HepG2 cells were incubated with meloxicam (80 μM), and harvested at the indicated time points. (B, C) HepG2 cells were incubated for 72 h with meloxicam (80 μM) in the presence and absence of PGE2 (3 μM) (B) or rh-MMP-2 (25 ng/mL) (C). The above harvested cells were subjected to Western blot analysis. The band density in each assay was measured and normalized to that of GAPDH, respectively. Data represent three independent experiments. “**”, indicates a highly significant (<i>P</i>&lt;0.001) difference.</p