Inhibitory effect of IRAK1/4 inhibitor on the secretion of IFN-γ and IL-17 by CD4⁺T cells from active VKH patients (n = 10) and normal controls (n = 11).

Abstract

<p>Cells were cultured with or without IRAK1/4 inhibitor in the presence of anti-CD3 and anti-CD28 antibodies for 3 days. Meanwhile, IL-18 or IL-1β was also added to the cultures. The level of IFN-γ or IL-17 was measured by ELISA. A. In the presence of IL-18, IFN-γ production by CD4⁺T cells from patients with active VKH disease (n = 10) and normal controls (n = 11). Results are expressed as means ± SD. B. In the presence of IL-1β, IL-17 production by CD4⁺T cells was measured in patients with active VKH disease (n = 10) and normal controls (n = 11). Results are expressed as means ± SD.</p