Mice with loss of SK1 in hematopoietic cells exhibit splenomegaly with DSS-induced colitis.

Abstract

<p>Bone marrow transplants were performed with WT and SK1^−/− mice. Following 6 weeks of rest, mice were administered either regular drinking water or water containing 5% DSS for 5 days. <b>A</b>) Change in body weight was assessed. Data represent mean ±SD, n≥6 for each treatment group; (significance at Day 5 =  *WT^WTBM, **WT^SK1BM, **SK1^WTBM); *p<0.05, **p<0.01, ***p<0.001 vs strain Day 0. <b>B</b>) Spleen weight and <b>C</b>) colon length were assessed following treatment. <b>D</b>) Pathology damage scores were determined by a pathologist in a blinded fashion with H&E sections of colon tissue. Data represent mean ±SD, n≥6 for each treatment group; *p<0.05, **p<0.01, ***p<0.001 vs strain untreated, #p<0.05 as compared to WT^WTBM DSS treated, %p<0.05 as compared to SK1^SK1BM DSS. For the X-axis: regular text refers to the host genotype and the superscript to the bone marrow genotype.</p