Cluster map of CULT domain proteins.

Abstract

<p>The main clusters are named as described in the text and the domain architecture of the proteins in the respective cluster is shown. For this map, we searched the nr database at NCBI with PSI-Blast, using the CULT domain of human cereblon as a query. After convergence, we extracted all proteins above the cutoff of E = 0.005 and clustered them in CLANS using their all-against-all pairwise similarities as measured by BLAST P-values. Clustering was done to equilibrium in 2D at a P-value cutoff of 1e-10 using default settings.</p