Iridium(III)-Catalyzed C‑7 Selective C–H Alkynylation of Indolines at Room Temperature

Abstract

An iridium-catalyzed direct C-7 selective C–H alkynylation of indolines at room temperature, for the first time, has been developed via C–H bond activation. Furthermore, the first example of direct C–H alkynylation of carbazoles at the C1 position is also achieved. More importantly, the resulting product can be readily transformed into C7-alkynylated indoles, further widening the C-7 derivatization of indoles and highlighting the synthetic utility of this methodology