Incidence rates and hazard ratios of ischemic stroke after the initiation of conventional and atypical antipsychotic medications.

Abstract

<p>(SMR, standardized morbidity ratio)</p><p>* (No. of events/total No. of days per 365 days)× 1,000.</p><p>† Adjusted for age, gender, presence or absence of dementia (F00-F03, G30, G31.8), depression (F32–33, F34.1, F41.2), dyslipidemia (E78.0), coronary heart disease (I21-I25), COPD (J40-J44, J47), and the use of antidepressants, benzodiazepine, anticoagulants, or antithrombotic agents during the follow-up period.</p><p>SMR weighted and multivariable adjusted HR after exclusion of the patients whose propensity score was > 99.99 in quetiapine, < 0.05 in olanzapine, > 0.90 in haloperidol, and < 0.05 in chlorpromazine.</p><p>Incidence rates and hazard ratios of ischemic stroke after the initiation of conventional and atypical antipsychotic medications.</p