XN4 induces apoptosis in CML or normal primitive and committed progenitors <i>in vitro</i>.

Abstract

<p>(A) XN4 induced apoptosis in CML CD34⁺CD38^—primitive and CML CD34⁺CD38⁺-committed progenitors. CML CD34⁺CD38^- primitive and CD34⁺CD38⁺ committed progenitors were exposed to XN4 at the indicated concentrations for 48 h. (B) Apoptosis in CML primitive and committed progenitors was analyzed by FACS as the percentage of cells positively labeled with Annexin V-APC (** <i>p<</i>0.01 vs control group, n = 3). (C) Apoptosis in normal primitive and committed progenitors from normal bone marrow was analyzed by FACS as the percentage of cells positively labeled with Annexin V-APC (n = 3).</p