<p>* two stage least square results: (1–0.97) / (0.922–0.496) = 0.07</p><p>HR: 93%, 95% CI; 0.2%–13.6%; <i>p</i> = 0.048</p><p>Marginal effect of different treatment on severe vascular events using instrumental variable analysis for three years follow-up (<i>n</i> = 1541).</p