Representative Ca²⁺ responses of TSCs from WT mice.

Abstract

<p>Stimuli tested were IMP (1mM), 4 L-amino acids from different side-chain groups (MPG (10mM), Ser (20mM), Arg (10mM), and Gln (10mM)), and L-amino acids with IMP. [A] Ca²⁺ responses of 3 sample TSCs. Each cell was tested with all 9 stimuli. The responses of the three cells are examples of some of the different response patterns to the array of stimuli. The bar above each stimulus trace represents stimulus application time (30 sec). [B] Mean±SEM amplitude of Ca²⁺ increase above baseline for responsive cells only, i.e. cells with a change in Ca²⁺ ≥5%. Numbers in parenthesis are the number of cells.</p