Defect in antigen-induced NHR in antigen-specific IgE-Tg mice.

Abstract

<p>IgE-Tg mice as well as antigen-immunized mice and T cell-transferred mice were challenged 3–4 times with OVA or saline, as shown in Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146686#pone.0146686.g002" target="_blank">2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0146686#pone.0146686.g006" target="_blank">6</a>. Six hours after the 3rd challenge, antigen-specific serum IgE, IgG, IgG₁, IgG_2a, IgG_2b, and IgG₃ were determined (A). The number of sneezes evoked by histamine (B) and accumulation of lymphocytes, neutrophils, and eosinophils in NALF (C) of IgE-Tg mice were examined 6 h after the 4th challenge. Data are expressed as mean ± SEM for 4–8 animals. *<i>p</i> < 0.05, **<i>p</i> < 0.01 (Dunn’s test). N.D.: not detectable.</p