Local BDNF promotes bone formation after osteotomy in the mandible.

Abstract

Micro-computed tomography images in the osteotomy at day 28 in rat. (A) The area of osteotomy was indicated by arrow (A). Twenty-eight days after osteotomy, exogenous BDNF accelerated regeneration of the cortex and induced osteosclerotic changes in the surrounding cortical bones (A). (B) Buccal cortical bone areas around osteotomy injury within 1,800 μm2 were measured using graphics software. The bone area was significantly wider in BDNF treated group.</p