WHO program «MONICA-psychosocial»: insomnia and biological markers in the male population aged 25-64 years

Abstract

Objective: to study the association polimorfizma-G308A gene tumor necrosis factor TNF-α and sleep disturbances in the male population aged 25-64 in metropolis of Western Siberia (Novosibirsk). Methods: Under the III screening of the WHO program «MONICA-psychosocial» a representative sample of men 25-64 years were surveyed (n = 657 men, mean age - 44, 3 ± 0,4 years responsum - 82.1%) in 1994 in Novosibirsk. For assessment of sleep levels scale Jenkins was used. Procedures have been standardized and strictly comply with the requirements of the protocol of the «MONICA». Genotyping of polymorphisms studied gene-G308A tumor necrosis factor TNF-α was conducted in the laboratory of molecular genetic in Research Internal Medicine and Preventive Medicine. Statistical analysis was performed using the software package «SPSS-11,5». Results: The level of sleep disorders in the male population aged 25-64 was 48.3%: evaluation of sleep as «fair» was 39.6%, «bad» - 7.6%, «very bad» - 1.1%. Genotype G/G gene TNF-α was in 79.1% of individuals, the genotype A/G - 19% of cases and genotype A/A was in 1.9% of men. Men carrying the genotype G/G of TNF-α gene are more likely to assess their sleep as «good» (98.3%), compared to those carrying other genotypes. In contrast subjects with heterozygous genotype A/G of TNF-α gene are more likely to estimate their sleep as «fair» (30%) than «good» (15.2%) in all groups. Conclusion: It was determined a heterozygous genotype A/G of TNF-a gene is most frequently associated with sleep disorders