We construct a three family flipped SU(5) model from Z12−I orbifold with one Wilson line. The gauge group is SU(5)×U(1)X×U(1)2×[SU(2)×SO(10)]′. This model does not derive any nonabelian group except SU(5) from E8, which is possible only for two cases, one in Z12−I and the other in Z12−II. We present all possible Yukawa couplings. We place the third family in the twisted sectors and two light families in the untwisted sector. From the Yukawa couplings, the model provides the R-parity, the doublet-triplet splitting, and one pair of Higgs doublets. It is also shown that quark and lepton mixings are possible. In addition, b−τ unification is achieved, and ντ mass can be in the sub-eV range. So far we have not encountered a serious phenomenological problem. There exist vectorlike flavor SU(5) exotics (including \Qem=±61 color exotics and \Qem=±21 electromagnetic exotics) and SU(5) singlet vectorlike exotics with \Qem=±21 which can be removed near the GUT scale