Cancer treatment is one of the most important research fields
of modern medicine.
In the last decades, targeted molecular therapies showed pr
osperous results. These treatments
achieve tumor regression with limited side-effects. Mathem
atical models were posed which
describe the dynamics of tumor regression under the applied
control. The current paper
investigates antiangiogenic therapy, which inhibits the t
umor to grow its own endothelial
capillaries and thus inhibits tumor to grow over a certain si
ze. Many different control approaches
were elaborated and published since the model formulation w
as posed. The aim of this paper
is to give an overview of these methods and results, and to rev
iew the work carried out by the
authors
