SARs on an 835 kb DNA fragment from the Drosophila genome.

Abstract

We have investigated the loop organization of a 835 kilobases DNA fragment from the Drosophila genome. This analysis has focused on the periodicity of the distribution of anchoring sequences (SARs) and its relationship to the distribution of A,T-rich regions, transcription units, repeated elements, putative replication origins and topoisomerase II cleavage sites. Altogether, the data support the idea of an active participation of SARs to the structural organization and functioning of this eukaryotic genome.</jats:p