背景和目的肝移植是治疗终末期肝病的有效手段,但术后免疫抑制剂的长期服用不仅给患者带来了沉重的经济负担,而且会导致严重的副作用。因此,研究如何诱导肝移植免疫耐受成为治疗肝移植术后免疫排斥反应的一个新方向。本实验研究的目的是分离、纯化、扩增脂肪间充质干细胞(adipose-derivedstemcells,ADSCs),对其生物学特性和免疫学特性与骨髓间充质干细胞(bonemarrowmesenchymalstemcells,BMSCs)进行比较,并就其在保护大鼠原位肝移植急性排斥反应的中所起作用进行探索性研究。 研究方法分离、纯化、扩增大鼠脂肪和骨髓来源间充质干细胞,将两种细胞进行形态、表面标...Background and Objective Organ transplantation is an acceptable therapy for many end-stage liver diseases. However, the balance between prevention of acute rejection and immunosuppressant-induced toxicity remains elusive. One strategy to overcome these limitations is tolerance induction. Mesenchymal stem cells (MSCs) inhibit the immune response in vitro, and thus are promising candidate cells to ...学位:医学硕士院系专业:医学院临床医学系_外科学学号:2452007115423