背景和目的 血管内皮生长因子(vascularendothelialgrowthfactor，VEGF)是已知作用最强的促血管生成因子之一，且研究表明VEGF在肿瘤的发生发展过程中起重要作用。VEGF基因上存在多个多态性位点，其中VEGF基因启动子区上游-2578C/A和下游+936C/T单核苷酸多态（singlenucleotidepolymorphism，SNP）已被证明可影响VEGF蛋白表达，且与多种疾病的发生发展相关。本课题通过研究内皮生长因子（VEGF）936*T/C单核苷酸多态性了解该突变位点对VEGF表达的影响及其功能效应。 方法 采用聚合酶链反应-限制性片段长度多态性（P...Background and aims Vascular endothelial growth factor (VEGF) is one of the powerful factors to facilitate angiogenesis as we know so far. Previous studies indicated that VEGF might play a critical role in the development of tumor. At least 30 single nucleotide polymorphisms (SNPs) exist in the VEGF gene. Among them, the two VEGF polymorphisms (-2578C/A and +936C/T) have been reported to affect t...学位：医学硕士院系专业：医学院临床医学系_肿瘤学学号：2452009115306
