The experience and positioning of affect is a material-discursive-intrapsychic experience, which can be interrogated through the examination of the intersubjective realm. This paper examines ways in which women experience and negotiate premenstrual change in affect, positioned as premenstrual syndrome (PMS), drawing on in-depth interviews conducted with 58 women. All of the women interviewed described premenstrual changes in affect in a similar manner, as being characterised by intolerance, irritation, emotional sensitivity, feeling more negative towards others, and feeling overwhelmed in the face of life’s demands. Without exception, women expressed a desire to be alone premenstrually, in order to escape relational demands and responsibilities, to reduce stimulation, or to avoid conflict. The way that these premenstrual changes and the woman’s desire to be alone were positioned by the woman’s partner, and dealt with within relationships, provided the material and discursive context for the woman’s experience and negotiation of PMS. Women whose partners were accepting and supportive were more likely to take up a position of awareness, acceptance and self-care in relation to premenstrual change, whilst women whose partners were unsupportive were more likely to engage in self-castigation and self-pathologization. This suggests that intersubjectivity, the examination of subjectivity and affect in the context of relatedness, will be a fruitful avenue of exploration for critical psychologists, as well as for researchers interested in the complexity of women’s premenstrual experiences