REGULARITIES OF HYPOCHLORITE MINERAL-ANION INTERACTION WITH LIPIDS OF MAN'S BLOOD LIPOPROTEINS AND LIPOSOMES

Abstract

It has been determined on the lipoproteins of the man's blood that the lipids LNP have been subjected to the largest oxidation changes under action of the hypochlorite in the comparison with LONP and LVP. It has been determined in the investigated oxidation systems (liposomes from egg phosphatidyl choline, dimyristoylphosphatidyl choline, colloid dispesion and LNP) the same set of the oxidation products is formed. The set of the formed cholesterin oxyderivatives doesn't depend upon the access rate to the hypochlorite. At interaction of the hypochlorite with cholesterin it has been determined that the cholesterin structure change takes place only accrording to the C3, C6 and C7 position. No one derivative oxidated according to the hydrocarbon tail has been discoverd in the mixture of the products. The methods for preparative extraction and identification of the cholesterin oxyderivatives and its esters have been developedAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio