Sex differences in the associations of socioeconomic status with stroke in the Turkish Population

Abstract

Abstract Background Low SES status is associated with the risk of stroke, with sex differences in the risk profiles. Recent evidence suggests that this association may differ in middle-income countries. We explored this association in the Turkish population. Methods The database of the Chronic Diseases and Risk Factors Survey in Turkey from 2013 and 2019 was used. The education level and employment status of the participants were chosen as a proxy indicator for SES. Cox regression analyses were conducted to assess the effect of SES on incident stroke controlled by age, settlement, behavioral and biological risk factors. Interaction terms were introduced to the Cox models to assess the multiplicative interaction between sex and SES on the risk of stroke. Results The study included 13 975 participants; 7 450 females (53.3%) and 6525 males (46.7%). During 74.2±9.87 months of follow-up, 108 strokes occurred among females (2.34 cases per 1000 person-years) and 81 stroke cases occurred among males (2.01 cases per 1000 person-years). Completion of primary school education was associated with decreased risk of stroke (HR = 0.46, 95%Cl: 0.25-0.84) among males. Education level had a linear protective effect against stroke among females after adjustment for behavioral and biological risk factors (HR = 0.50, 95%Cl: 0.30-0.81; HR = 0.30, 95%Cl: 0.12-0.71; respectively for primary education and secondary or higher education). Employment status did not predict the incident stroke for both sexes. There was no evidence of an interaction between sex and education (p = 0.68). Conclusions In this Turkish population, stroke risk was greater in women than in men. Increasing education was associated with a reduced risk of stroke in Turkish women, whereas the only completion of primary education was protective for men, with no further protection at increased educational levels. Further exploration of sex and gender risk differences in moderate-income countries may lead to improved efforts at risk reduction. Key messages Education level as a social determinant of health in middle-income countries may affect men and women differently with regards to the risk of stroke Understanding sex differences in the associations of socioeconomic status with stroke may lead to improved efforts at risk reduction of stroke in MICs. </jats:sec