Benito-Lopez, Fernando

Byrne, Robert

Coyle, Shirley

Curto, Vincenzo F.

Diamond, Dermot

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UNIVERSITY	  COLLEGE	  DUBLIN	  	  	  	  	  	  DUBLIN	  CITY	  UNIVERSITY	  	  	  	  	  	  TYNDALL	  NATIONAL	  INSTITUTE	  	  Vincenzo F. Curto, Shirley Coyle, Robert Byrne, Dermot Diamond, Fernando Benito-Lopez  CLARITY: Centre for Sensor Web Technologies, National Centre for Sensor Research, School of Chemical Sciences,  Dublin City University, Dublin 9, Ireland vincenzo.curto2@mail.dcu.ie Sweat is naturally generated during exercise, and real-time monitoring of its composition provides very rich information about the physiological condition of the individual.1 There are several factors that correlate sweat pH and health, however, relatively little is known about them due to the difficulties in performing realtime on-body measurements during exercise.  The autonomous, wearable and flexible micro-fluidic device based on ionogels3, ionic liquid polymer gels, is used to monitor the pH of sweat generated during exercise. The [P4,4,4,4]+[dca]- ionic liquid (IL) is employed to synthetise the poly(N-isopropyl-acrylamide) ionogel by UV-photopolymerization.  PN NC CNTetrabutyl-phosphonium  dicyanamide [P4,4,4,4]+ [dca]-  N-isopropylacrylamide  N,N’-methylene-bis(acrylamide) pH 3 pH 9 pH 4 pH 4.5 pH 5 pH 5.5 pH 6 pH 6.5 pH 7 pH 7.5 pH 8 pH 8.5 pH 9.5 pH 3.5 pH 10 Ionogels dry Micro-fluidic chip tested with artificial sweat (ISO 3160-2) at different pH’s Whole body sweat collection technics2 Chemical Barcodes for Real-Time Sweat pH  Monitoring Based on Wearable Micro-fluidic  Platforms Incorporating Ionic Liquids Barcode fabrication process  Sweat pH determination using the micro-fluidic chip during a 50 min. training period  Surface Oxidation by O2 plasma Silanisation with 7- octenyltrichlorosylane 4 REFERENCES [1] D. Granger, M. Marsolais, J. Burry, R. Laprade, Am. J. Physiol.-Cell Physiol. 2003, 285, C1047-C1058. [2] Shirreffs S M , Maughan R J J Appl Physiol 1997;82:336-341 [3] F. Benito-Lopez, R. Byrne, A. M. Raduta, N. E. Vrana, G. McGuinness, D. Diamond, Lab Chip 2010, 10, 195-201. [4] S. Samanta,  J. Locklin, Langmuir 2008, 24, 9558-9565 CONCLUSIONS In this work, the fabrication, characterization and the performance of a micro-fluidic system based on ionogels for monitoring in real time mode the pH of the sweat generated during an exercise period has been presented. The ionogel-dye interactions ensure no leaching of the dyes during experiments, providing long durability of the device. The approach presented here can provide immediate feedback regarding sweat composition, pH, to individuals during exercise period. ACKNOWLEDGMENT This work was supported by Science Foundation Ireland under grant 07/CE/I1147 and the Research Career Start Programme 2010 fellowship form Dublin City University. PharmChek Sweat Patch  OHOHOHOHOHOHSiClCl3OOOOOOSi 3Si 3Cl

Chemical barcodes for real-time sweat pH monitoring based on wearable microfluidic platforms incorporating ionic liquids

http://doras.dcu.ie/16259/1/Poster_CASi_2011_Curto_Vincenzo_Fabio.pdf

Chemical barcodes for real-time sweat pH monitoring based on wearable microfluidic platforms incorporating ionic liquids

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