We present a measurement of the absolute branching fraction for D^0→K^-π^+ using the reconstruction of the decay chain B̅ →D^(*+)Xℓ^-ν̅ , D^(*+)→D^0π^+ where only the lepton and the low-momentum pion from the D^(*+) are detected. With data collected by the CLEO II detector at the Cornell Electron Storage Ring, we have determined B(D^0→K^-π^+) = [3.81±0.15(stat)±0.16(syst)]%
