Measurements of the exclusive branching fractions B(D^0→π^-e^+ν_e) and B(D^0→K^-e^+ν_e), using data collected at the ψ(3770) with the Mark III detector at the SLAC e^+e^- storage ring SPEAR, are used to determine the ratio of the Kobayashi-Maskawa matrix elements │V_(cd)/V_(cs)│^2 =0.057_(-0.015)^(+0.038)±0.005