Electronic Poster Presentations: P40BACKGROUND: Osteoarthritis (OA) is a common degenerative disease among elderly with some cases associated with hypertension. Endothelin-1 (ET-1) is a hypertension agonist which has been shown to induce type I collagen secretion and inhibit mineralisation in osteoblasts. Upregulation of transforming growth factor beta 1 (TGFβ-1) is associated with the onset of OA. Crosstalks between TGFβ-1 and ET-1 may increase the OA ...postprin
