Reactions that convert carbon–hydrogen (C–H) bonds into carbon–carbon (C–C) or carbon–heteroatom (C–Y)
bonds are attractive tools for organic chemists, potentially expediting the synthesis of target molecules via functional
group interconversion. More explorative studies have shown Complex Induced Proximity Effect (CIPE) to be a solutionprovider
for the synthesis of bioactive compounds. This might act as excellent pathfinders to new drugs for combating
microorganisms’ resistance challenges to old existing drug. So, a constant review into CIPE and lithiation chemistry is
crucial because they offer excellent pathways to new heterocyclic compounds which are essential agents in drug design and discovery
