The prevalence of depression is higher among African American college students compared to their White counterparts. They are also more likely to disclose feelings of depression on Twitter. The aim of this exploratory study was to answer the following questions: What are the most common themes of depression-related tweets among African American college students? Are there differences in the social network characteristics of college students that have posted a depression-related tweet or retweet and those who have not? Content and social network analyses were conducted. The study results showed the most common themes focused on feelings of depression, casual mentions, and supportive messages. In addition, we observed that the social networks of users posting depression-related tweets have more mutual connections with their friends than the users who did not post a depression-related tweet. These findings may help to inform the design of social media interventions for African American college students