The current research presents a theoretically sound model on information systems (IS) characteristics’ effects on end-users’ perception of computer self-efficacy and outcome expectations. Based on the IS success model and the social cognitive theory, the relationship among factors with regard to small- and medium-sized enterprises (SMEs) in Taiwan is examined. Using mail survey, 284 usable responses are obtained, and the total response rate is recorded at 51.64%. Structural equation modeling (SEM) is employed to assess the relationships among related constructs. In modeling the results of data analysis, it is shown that (1) there are no direct links between both information quality and service quality with computer self-efficacy, but the effect of system quality is observed; (2) the relationship between both system quality and service quality with outcome expectations is significant, but that with information quality is not; and (3) outcome expectations mediates the impacts of computer self-efficacy on end-users’ satisfaction. Finally, the implications of the results are provided, and directions for future research are discussed