Avari, Parizad

Averill, Sharon

Colom, Bartomeu

Huang, Wenlong

Imhof, Beat A

Nourshargh, Sussan

Priestley, John V

Brain Behavior and Evolution

PubMed

JAM-C is a junctional adhesion molecule, enriched at tight junctions on endothelial and epithelial cells, and also localized to Schwann cells at junctions between adjoining myelin end loops. The role of JAM-C following peripheral nerve injury (PNI) is currently unknown. We examined the localization of JAM-C after sciatic nerve crush injury in adult rats. JAM-C immunoreactivity was present in paranodes and incisures in sham surgery control nerve, but distal to the crush injury significantly decreased at three and 14 days. JAM-C was re-expressed at 28 days and, by 56 days, was significantly increased in the distal nerve compared to controls. In a 7-mm length of sciatic nerve sampled distal to the crush site, the densities of JAM-C immunoreactive paranodes increased in the distal direction. Conversely, the densities of JAM-C immunoreactive incisures were highest immediately distal to the crush site and decreased in the more distal direction. Further analysis revealed a strong correlation between JAM-C localization and remyelination. Fifty-six days after crush injury, greater densities of JAM-C paranodes were seen compared to the nodal marker jacalin, suggesting that paranodal JAM-C precedes node formation. Our data are the first to demonstrate a potential role of JAM-C in remyelination after PNI

Imhof, Beat

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The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats

Parizad Avari

Wenlong Huang

Sharon Averill

Bartomeu Colom

Beat A. Imhof

Sussan Nourshargh

John V. Priestley

Crossref

Brain and Behavior

The spatiotemporal localization of JAM‐C following sciatic nerve crush in adult rats

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The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats

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