Template synthesis of N,N 0-bis(4-acetyl-5-methylpyrazole-3-yl)formamidine (ampf) was performed starting from 4-acetyl-3- amino-5-methylpyrazole (aamp) andCH(OC2H5)3 in methanol in the presence of CuCl2, Cu(NO3)2, orNi(NO3)2. The ligand was isolated in coordinated form as [Cu(ampf )Cl2], [Cu(ampf )(MeOH)(NO3)2]MeOH, and [Ni(ampf )(MeOH)2(NO3)]NO3 correspondingly. The compounds were characterized by elemental analysis, Fourier-transform IRand electronic spectroscopy, thermal analysis, single-crystal X-ray diffraction, and quantumchemical (density functional theory) calculations. The density functional theory calculations provided information on the metal�ligand interactions in the complexes and assisted the assignment of the FT-IR spectra. The antiproliferative activity of the complexes and the ligand precursor, aamp, was tested against human myelogenous leukaemia K562, colon adenocarcinoma HT29, and cervix carcinoma HeLa.JRC.E.3 - Materials researc
