Automated scoring of tumor-infiltrating lymphocytes informs risk of death from thin melanoma: A nested case-case study (Letter)

Abstract

To the Editor: Thin primary cutaneous melanomas (thickness ≤1.0 mm) have an excellent prognosis, with 10-year melanoma-specific survival rates of over 94%.1 However, they constitute the majority of new melanoma diagnoses, and due to their frequency account for approximately one-quarter of total melanoma deaths.2 While accurate identification of high-risk patients could facilitate heightened surveillance and potentially systemic therapy, standard prognostic factors such as ulceration, mitotic rate, and sentinel node biopsy are rarely positive in thin melanoma, restricting their utility in stratification.3Full Tex