A Computational Metabolic Model of the NG108-15 cell for High Content Drug Screening with Electrophysiological Readout

Abstract

Computational Systems Modeling could play a significant role in improving and speeding up of the drug development process. By the incorporation of cellular modeling into a High Information Content Drug Screening platform the information content of the pharmacological test could be significantly increased through a deeper understanding of cellular pathways and signaling mechanisms. Unfortunately, many of the cellular signaling pathways in the cells are yet to be explored. Moreover, which is an even larger problem, their integration into a functional signaling network at the whole cell level is almost unknown or untested. Thus, there is an urgent need to develop a data-driven functional whole-cell model which enables the correlation of biochemical and physiological experimental results at the whole cell level with partial information available for the metabolic an