Acinetobacter baumannii is a Gram-negative microorganism and a member of the ESKAPE pathogen group. It poses a significant threat to public health due to its association with nosocomial infections and high mortality rates. In recent years, there has been an increasing emergence of multidrug-resistant strains, a phenomenon linked to the misuse and overuse of antibiotics, including their use in livestock farming.This study aims to provide a detailed description of the resistance mechanisms in Acinetobacter baumannii against tetracyclines, beta-lactams, aminoglycosides, and fluoroquinolones.To achieve these aims, we conducted a literature review of scientific articles published in PubMed and Google Scholar.The development of resistance in Acinetobacter baumannii is associated with alterations in cell membrane permeability, the presence of efflux pumps, protection of antibiotic targets within the bacterial cell, and direct inactivation of antibiotics. Understanding the resistance mechanisms of Acinetobacter baumannii and other ESKAPE pathogens is crucial for safeguarding public health
