[Abstract] We report here the draft genome sequences of Klebsiella pneumoniae strains Kp1803 and Kp3380 isolated during a large outbreak at A Coruña Hospital in Spain. The final genome assemblies for Kp1803 and Kp3380 comprise approximately 6.6 and 6.1 Mb, respectively, and both strains have G+C contents of 57.2%.This work was supported by grants from the Spanish Society of Infectious Diseases and Clinical Microbiology to A.P. and by projects PI11/01034 and P14/00059 to M.P., integrated in the National Plan for Scientific Research, Development and Technological Innovation 2013–2016 and funded by the Instituto de Salud Carlos III (ISCII), General Subdirection of Assessment and Promotion of the Research-European Regional Development Fund (FEDER) “A Way of Making Europe.” We also thank the Spanish Network for Research in Infectious Diseases (REIPI RD12/0015/0014 to G.B.), cofinanced by the European Development Regional Fund (EDRF) and by the Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad