Alzheimer's disease (AD) is one of the basic neurodegenerative diseases and the most extreme common state of dementia. Described through the loss of learning, memory, critical thinking, language, and different abilities to address, AD applies an adverse consequence on every patients' and families' style of life. Despite the fact that there were enormous advances in data , the basic pathogenesis and progression of AD, there's no solution for AD. The disappointment of several molecular focused pharmacologic clinical preliminaries closes in a rising research shift towards non-invasive medicines. We, first and foremost, assessed the pathological changes of AD and the requesting circumstances for AD research. We then, at that point, added those non-invasive medicines and referenced the components which can affect the results of those therapies. Furthermore, we assessed the results of those therapies and the suitable components underlying those outcomes. At long last, we summed up the requesting circumstances of the Photobiomodulation cure in future AD studies and clinical applications. We presumed that it would be essential to perceive the exact fundamental components and find the optimal cure parameters to upgrade the translational value of the Photobiomodulation treatment