STAT roles in IL-15 and IL-21 driven LMP1 and LMP2 promoter epigenetic remodeling.

Abstract

(A-C) ChIP-qPCR analysis of LMP1 promoter H3K9me2 (A), H3K9me3 (B) or H3K27me3 (C) abundances from GM12878 expressing control or STAT3/5A/5B targeting sgRNAs, mock treated or treated with 100ng/ml IL-15 or IL-21 for six days. (D-F) ChIP-qPCR analysis of LMP2 promoter H3K9me2 (D), H3K9me3 (E) or H3K27me3 (F) abundances in GM12878 expressing control or STAT3/5A/5B targeting sgRNAs, mock treated or treated with IL-15 or IL-21 for six days. Mean ± SD input % of n = 3 replicates are shown, *p p (TIFF)</p