Notwithstanding the rising natural and vaccines mediated immunity, a several nations have encountered a resurgence of the Covid disease of 2019 (Coronavirus) because of the development of severe acute respiratory syndrome Covid 2 (SARS-CoV-2) variations. From Alpha to Omicron, the variants of concern (VOC) have advanced several spike protein changes that might affect infection characteristics, like contagiousness and antigenicity. In this review, we depict the advancement of SARS-CoV-2, sum up current information on epidemiological and clinical highlights of the variants, and talk about the response techniques as far as vaccines to decrease the burden of Coronavirus