Purpose: The purpose is to investigate the effect of cefazolin sodium on perioperative prophylactic anti-infection in patients undergoing gynecological surgery. Methods: 112 cases of gynecological surgery from January 2019 to April 2020 were divided into the control group and the observation group, with 56 cases in each group. They were given cefazolin sodium + metronidazole and cefazolin sodium monotherapy respectively. The perioperative white blood cells and the incidence of adverse reactions of the two groups were compared. Results: There was no difference in the normal rate of white blood cell count between the observation group and the control group (P &gt; 0.05), and no adverse reaction in the observation group, which was significantly lower than 7.14% in the control group (P &lt; 0.05). Conclusion: the use of cefazolin sodium in perioperative period of gynecological surgery can prevent infection, with advanced security, less adverse reactions and high value

Sai, Na

English

Advanced Emergency Medicine (E-Journal)

                                ORIGINAL ARTICLE Advanced Emergency Medicine Volume 10 Issue 1 | 2021 | 11 Effect of Cefazolin Sodium on Perioperative Prophylactic An-ti-Infection in Patients Undergoing Gynecological Surgery Na Sai* Pharmacy Department of Chifeng Municipal Hospital, Chifeng 024000, Neimeng, China. E-mail:22554730@qq.com Abstract: Purpose: The purpose is to investigate the effect of cefazolin sodium on perioperative prophylactic an-ti-infection in patients undergoing gynecological surgery. Methods: 112 cases of gynecological surgery from January 2019 to April 2020 were divided into the control group and the observation group, with 56 cases in each group. They were given cefazolin sodium + metronidazole and cefazolin sodium monotherapy respectively. The perioperative white blood cells and the incidence of adverse reactions of the two groups were compared. Results: There was no dif-ference in the normal rate of white blood cell count between the observation group and the control group (P > 0.05), and no adverse reaction in the observation group, which was significantly lower than 7.14% in the control group (P < 0.05). Conclusion: the use of cefazolin sodium in perioperative period of gynecological surgery can prevent infection, with advanced security, less adverse reactions and high value. Keywords: Cefazolin Sodium; Gynecological Surgery; Perioperative Period; Preventive Anti Infection 1. Introduction  Studies have shown that patients after gynecological surgery are mainly faced with postoperative infection and other problems, which belong to the high incidence of perioperative complications. If they cannot be pre-vented and controlled in time, it will lead to poor wound healing, prolong the recovery time of the disease, and cause serious symptoms and even death by infection, so it is necessary to prevent anti-infection of gynecological surgery patients during perioperative period[1]. At present, there are many drugs for postoperative infection in clinic, and cefazolin sodium belongs to a wide range of drugs, which has a positive inhibitory effect on Gram-positive bacteria and less adverse reactions. How-ever, at present, most of them are used in combination with metronidazole, it can better control the infection to a certain extent, but the adverse reactions after metroni-dazole use are serious, so we consider the use of cefazolin sodium single drug control method to observe the curative effect[2]. In this paper, the effect of cefazolin sodium on perioperative prophylactic anti infection in patients undergoing gynecological surgery is analyzed and discussed. 2. Data and methods 2.1 General information During January 2019 to April 2020, 112 cases of gynecological surgery were divided into control group and observation group, with 56 cases in each group. The control group was in 28-68 years old, with the average age of (48.11 ± 5.78) years old; the observation group was in 26-68 years old, with the average age of (47.76 ± 5.54) years old. There was no statistical significance be-tween the two groups (P > 0.05)  Inclusive indicators: 1) all patients underwent gyne-   Copyright © 2021 Na Sai doi: 10.18686/aem.v10i1.184 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 12 | Na Sai Advanced Emergency Medicine cological surgery smoothly without abnormality; 2) the experimental scheme was approved by the hospital ethics committee; 3) the patients agreed to the experiment and signed the consent form. Exclusion criteria: 1) previous allergic history of cephalosporins and metronidazole; 2) infection before operation; 3) no complete clinical data; 4) mental dis-eases; 5) blood diseases. 2.2 Method In the control group, cefazolin sodium and metro-nidazole were given 30 minutes before the operation. Cefazolin sodium (Huabei pharmaceutical, Hebei Huamin pharmaceutical, Guoyao Zhunzi h13020668) was given intravenously at a dose of 2.0 g, while metro-nidazole (Nanjing Zhengda Tianqing Pharmaceutical Co., Ltd., Guoyao Zhunzi h20023747) was given intrave-nously at a dose of 0.5 g. The drug should be given within 30 minutes; After operation, 4.0g cefazolin sodi-um and 1.0g metronidazole were given intravenously twice a day for 24-48h. The observation group was treated with cefazolin sodium monotherapy, and the same dosage of 2.0g was given 30 min before the operation, and 4.0g cefazolin sodium was given after the operation. The times and time of administration were the same as those of the control group. 2.3 Observation indexes The two groups of perioperative white blood cell situation comparison, if the white blood cell count is lower than 10*109/L, it is normal, while higher than 10*109/L, it is abnormal, and then the postoperative white blood cell count is tested. Adverse reactions in-cluded nausea and vomiting, headache and vertigo. 2.4 Statistical analysis The data of each observation index were qualitative data, n (%) was used to represent count data,  refers to test, and (x�  ± s) is used to represent measurement data, t refers to test. After statistical analysis by SPSS22.0 sta-tistical soft package, if the difference is significant and P < 0.05, there is statistically significance. 3. Results 3.1 Comparison of white blood cells in two groups during perioperative period There was no difference in the normal rate of white blood cell count between the observation group and the control group (P > 0.05), as shown in Table 1 below. 3.2 Comparison of the incidence of adverse reactions between the two groups There was no adverse reaction in the observation group, which was significantly lower than 7.14% in the control group (P < 0.05), as shown in Table 2 below.   Table 1. Comparison of white blood cells in two groups during perioperative period [n (%)]       Table 2. Comparison of incidence of adverse reactions between the two groups [n (%)] Group Nausea and vomiting Headache Vertigo Incidence Rate Control group (n=56) 2 2 0 4 (7.14) Observation group (n=56) 0 0 0 0 (0.00)  -- -- -- 4.148 P -- -- -- 0.042  2x2xGroup <10*109/L ≥10*109/L ≥15*109/L Control group  (n=56) 53 (94.64) 2 (3.57) 1 (1.79) Observation group (n=56) 52 (92.86) 2 (3.57) 2 (3.57) t 0.152 0.000 0.343 P 0.696 1.000 0.558  Advanced Emergency Medicine Volume 10 Issue 1 | 2021 | 13 4. Discussions  There is a high probability of infection after gyne-cological surgery, which is closely related to the anatom-ical structure of the female reproductive system. The female genital tract is close to the urethra and anus, so it is vulnerable to the invasion of bacteria. Therefore, it is very important to prevent perioperative infection. It is necessary to choose more appropriate and effective postoperative infection suppression measures, apply more effective drugs, and take effective measures, in order to pay attention to the safety of drug use and pre-vent the adverse reactions of patients after taking[3]. Data comparison showed that there was no differ-ence in the normal rate of white blood cell count between the observation group and the control group (P > 0.05), and no adverse reaction in the observation group, which was significantly lower than 7.14% in the control group (P < 0.05). The reason is analyzed. Cefazolin sodium is a kind of chelating macromolecule synthesized by cefazolin molecule, sodium ion and water molecule. It is a sort of crystal structure with strong stability, which has more drug effect than common cefazolin and can effec-tively resist Gram-positive bacteria. Moreover, after ad-ministration, the sulfur-containing group can be wrapped into a kind of cavity similar to a tunnel with better stabil-ity, which can effectively control its contact with the rubber plug, and the adverse reactions after drug use can be effectively controlled. Therefore, the simple use of drugs can also control the Gram-positive bacteria, playing the effect of drug combination[4]; on the analysis of drug use time, the rationality of preventive medication needs to be guaranteed. Generally speaking, the first 2-3 hours after the end of the operation belongs to the effec-tive period and decision period of infection control.  In this study, 30 minutes before the operation, anti-biotics intervention can be carried out at the first time after the incision appears, so as to ensure that the blood in the local tissue contains antibiotics during the incision exposure period. And it can kill the invasive bacteria during the operation to realize the effective control of infection and continuous medication 24-48 hours after the operation. It can continuously control postoperative and prevent possible infection during wound recovery, so that infection control is more ideal after use[5]; according to the analysis of adverse reactions, metronidazole is mainly used for anaerobic infection, but 15-30% of cases have adverse reactions, and the incidence of adverse re-actions is higher, so without using the drug, the control effect of adverse reactions is more ideal[6,7]. In conclusion, the use of cefazolin sodium in peri-operative period of gynecological surgery can prevent infection, with high security, less adverse reactions and more valuable. References 1. Xu Z, Zeng M, Zhang Y, et al. Clinical Observation of Cefazolin Sodium in Preventive Anti-Infection during Perioperative Period of Gynecology. Ad-vances in Clinical Medicine 2019; 9(10): 1159–1162. doi: 10.12677/ACM.2019.910179. 2. Guo Q. Safety and effectiveness of cefazolin sodium pentahydrate for injection in the treatment of gyne-cological infection and prevention of gynecological postoperative infection. China Health Industry 2014; 11(6): 88–89. doi:10.16659/j.cnki.1672-5654.2014.0 6.101. 3. Liu C, Lu Y. Efficacy of cefazolin sodium pentahy-drate in prevention of incision infection in gyneco-logical tumor surgery. Journal of Medical Forum 2011; 32(9): 137–138. doi: CNKI:SUN:HYYX.0.20 11-09-057. 4. Yan J, Ren Q, Zhou X, et al. Effect of cefazolin so-dium pentahydrate on patients with severe open fracture of limbs complicated with soft tissue injury and wound infection after operation. Contemporary Medicine Forum 2019; 17(15): 81–82. doi: CNKI:SUN:QYWA.0.2019-15-056. 5. Tong Y. Effect of cefazolin sodium on postoperative inflammatory factors and wound infection in ortho-pedic patients. Anti-Infective Pharmacy 2020; 17(5): 767–769. doi: 10.13493/j.issn.1672-7878.202 0.05-043. 6. Wang X, Peng Y. Clinical efficacy of cefazolin so-dium pentahydrate in prevention of gynecological surgical infection. Chinese Journal of Modern Drug Application 2010; 04(20): 91–92. doi: 10.14164/j.cn ki.cn11-5581/r.2010.20.174. 7. Guan Y, Liu Y. Efficacy of cefazolin sodium pen-tahydrate in prevention of incision infection in gy-necological tumor surgery. Journal of Medical Fo-rum 2020; 17(6): 913–915. 

Effect of Cefazolin Sodium on Perioperative Prophylactic Anti-Infection in Patients Undergoing Gynecological Surgery

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Effect of Cefazolin Sodium on Perioperative Prophylactic Anti-Infection in Patients Undergoing Gynecological Surgery

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