High-Performance Computing (HPC) have evolved to be used to perform simulations of systems where physical experimentation is prohibitively impractical, expensive, or dangerous. This paper provides a general overview and showcases the analysis of non-functional properties in RISC-V-based platforms for HPCs. In particular, our analyses target the evaluation of power and energy control, thermal management, and reliability assessment of promising systems, structures, and technologies devised for current and future generation of HPC machines. The main set of design methodologies and technologies developed within the activities of the Future and HPC & Big Data spoke of the National Centre of HPC, Big Data and Quantum Computing project are described along with the description of the testbed for experimenting two-phase cooling approaches

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