Boni, Maciej

Castoe, Todd

Jiang, Xiaowei

Lam, Tommy

Lemey, Philippe

Perry, Blair

Rambaut, Andrew

Robertson, David

English

Open Journal Systems at the Victoria University of Wellington Library

New Zealand Science Review Vol 76 (3) 202082AbstractEvolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemicMaciej F. Boni, Philippe Lemey, Xiaowei Jiang, Tommy Tsan-Yuk Lam, Blair W. Perry, Todd A. Castoe, Andrew Rambaut & David L. Robertson Nature Microbiology (2020) There are outstanding evolutionary questions on the recent emergence of human coronavirus SARS-CoV-2 including the role of reservoir species, the role of recombination and its time of divergence from animal viruses. We find that the sarbecoviruses – the viral subgenus containing SARS-CoV and SARS-CoV-2 – undergo frequent recombination and exhibit spatially structured genetic diversity on a reg- ional scale in China. SARS-CoV-2 itself is not a recombinant of any sarbecoviruses detected to date, and its receptor-binding motif, important for specificity to human ACE2 receptors, appears to be an ancestral trait shared with bat viruses and not one acquired recently via recombination. To employ phylogenetic dating methods, recombinant regions of a 68 genome sarbecovirus alignment were removed with three independent methods. Bayesian evolutionary rate and divergence date estimates were shown to be con-sistent for these three approaches and for two different prior specifications of evolutionary rates based on HCoV-OC43 and MERS-CoV. Divergence dates between SARS-CoV-2 and the bat sarbecovirus reservoir were estimated as 1948 (95% highest posterior density (HPD): 1879–1999), 1969 (95% HPD: 1930–2000) and 1982 (95% HPD: 1948–2009), indicating that the lineage giving rise to SARS-CoV-2 has been circu-lating unnoticed in bats for decades.Boni, M.F., Lemey, P., Jiang, X. et al. Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic. Nat Microbiol (2020). https://doi.org/10.1038/s41564-020-0771-4  and https://rdcu.be/b7nT0

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

https://ojs.victoria.ac.nz/nzsr/article/download/7820/6961

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

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