Pathways of liver tissue significantly influenced by chronic hypoxia exposure.

Abstract

(A) KEGG enrichment pathway bubble figure. Each bubble in the bubble plot represents a metabolic pathway (the top 20 with the highest significance are selected according to the p value). The abscissa where the bubble is located and the size of the bubble indicate the influence factor size of the pathway in the topological analysis. The larger the size, the larger the influence factor. The vertical axis of the bubble and the color of the bubble represent the p value of enrichment analysis (taking the negative common logarithm, that is, -log10 p-value). The darker the color, the smaller the p value, the more significant the enrichment degree. The rich factor represents the proportion of the number of differential metabolites in the pathway to the number of metabolites annotated in the pathway. (B) Differential abundance score map of all enriched metabolic pathways. The Y-axis represents the name of the differential pathway, and the coordinates on the X-axis represent the DA score. A score of 1 indicates that all identified metabolites in this pathway tend to be upregulated, and -1 indicates that all identified metabolites in this pathway tend to be downregulated. The length of the line segment indicates the absolute value of DA score, the size of the dot at the end of the line segment indicates the number of metabolites in the pathway, and the larger the dot indicates the more metabolites. The color of the line segments and dots is proportional to the DA score value. The darker the red is, the more inclined the overall expression of the pathway is to be up-regulated, and the darker the blue is, the more inclined the overall expression of the pathway is to be down-regulated.</p