DNA-Conjugated Cyclopropane Derivatives Constructed from Sulfonium Ylides with <i>α,β</i>-Unsaturated Ketones

Abstract

Here, we report a DNA-compatible reaction for the generation of cyclopropane derivatives using thiolides with α,β-unsaturated ketones in the absence of transition metal and N2 protection, which is convenient for DNA encoded library (DEL) construction. This approach allows the rapid and efficient production of a series of DEL libraries of potentially biologically active cyclopropanes and spirocyclopropyl oxindole derivatives

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